A drug combination dataset
ONeil_A375.RdAn example dataset from a large drug combination screening experiment, on the A-375 human melanoma cell line.
Usage
data(ONeil_A375)Format
A synergyscreen object, consisting of an initial run of 583 drug combinations on the A-375 human melanoma cell line. Contains a dataframe of summary statistics for 581 experiments, and a list containing two experiments that failed to process.
References
O'Neil J, Benita Y, Feldman I, Chenard M, Roberts B, Liu Y, Li J, Kral A, Lejnine S, Loboda A, Arthur W, Cristescu R, Haines BB, Winter C, Zhang T, Bloecher A, Shumway SD. An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies. Mol Cancer Ther. 2016 Jun;15(6):1155-62. doi: 10.1158/1535-7163.MCT-15-0843. Epub 2016 Mar 16. PMID: 26983881.